2005-03-19

    Historia de dos cromosomas

    El jueves comenté que se había publicado la secuencia completa del cromosoma X y me centré en las connotaciones sexistas, dejando para más adelante hablar de la evolución de este cromosoma y de cómo surge el dimorfismo cromosómico.

    Hace mucho, mucho tiempo, los cromosomas X e Y eran isomórficos. Esta pareja de cromosomas tenía un gen al que llamaremos SRY, que es el responsable de determinar el sexo del individuo. La determinación sexual no tenía por qué ser siquiera genética (alelos diferentes para cada sexo), podría ser ambiental (proteína termosensible, por ejemplo). El caso es que en una meiosis de estas que ocurren cada gametogénesis, un sobrecruzamiento salió mal y se produjo una inversión que afectó a la zona en la que estaba el bueno de SRY.

    ¡Ya la hemos liado! Ahora tenemos un cromosoma X "normal" y un cromosoma X con una inversión. Y si algo tiene importancia en citogenética, eso son las inversiones. Cuando en una meiosis dos cromosomas homólogos se aparean, si uno de ellos presenta una región invertida con respecto al otro, en esa región no hay homología secuencial, por lo que no se producen sobrecruzamientos. Los genes que estén dentro de una de estas inversiones quedan imposibilitados de recombinar, así que están ligados para siempre.

    Y así ocurrió que el pobre SRY quedó aislado junto con un número de otros genes. Ahora ya se podía producir una determinación cromosómica del sexo. La copia presente en uno de los cromosomas sería la activa, la otra la inactiva. (Esto pudo ocurrir, de hecho, nada más producirse la inversión, si esta interrumpiese la funcionalidad de la región reguladora, pero sólo estoy especulando.) Y ocurre que la copia activa determina el sexo masculino. Así tendríamos un cromosoma proto-Y, responsable de la masculinidad, y un cromosoma X. Ya dije, y reitero, que no hay cromosoma 'masculino', menos aún uno 'femenino'. La masculinidad la determina el Y, pero los genes responsables de la masculinidad están repartidos por todos los cromosomas, incluso el propio X. Y como los varones tienen un cromosoma X activo, al igual que las hembras, no podemos hablar en ningún caso del X como determinante femenino.

    Cosas de la herencia cromosómica, si un macho es X/proto-Y y una hembra es X/X, entonces nunca jamás se juntarán dos proto-Y en la línea germinal de un individuo, de modo que jamás recombinarán, mientras que los X siguen encontrándose en las hembras. Matizo. No hay recombinación en la zona invertida, porque el resto del proto-Y es idéntico al X. La gracia está en que al menos 5 reajustes cromosómicos han ocurrido en el Y, de modo que la recombinación en machos cada vez se limita más y más. Y esto termina afectando al tamaño del Y, que se va reduciendo más y más, hasta llegar a la ridiculez que véis ahí arriba.

    El caso es que si el Y va perdiendo genes que el X mantiene, entonces los machos tienen la mitad de dosis para estos genes que las hembras. Y si estos genes son normalitos, no relacionados con lo femenino que sea uno, pues es evidente que algo hay que inventarse para que machos y hembras tengan la misma expresión genética del cromosoma X (compensación de dosis).

    La solución la podemos observar en forma de corpúsculo de Barr:



    Los cromosomas X tienen un locus, XIST, que al transcribirse produce un RNA que se une al DNA del cromosoma X por todas partes, inactivando la expresión de los genes (menos la del propio XIST). La regulación de este gen es algo complicada, así que no entraré en detalles, pero el caso es que por una serie de interacciones genéticas de retroalimentación negativa, si hay dos cromosomas X, uno y sólo uno se inactiva. Si sólo hay uno, permance activo.

    ¿Qué cromosoma se inactiva? Completamente aleatorio. De ahí vienen los fenotipos mosaico asociados al X. Cuando cada X porta un alelo diferente, eso significa que habrá linajes celulares que expresen un alelo y otros que espresen el otro.

    Como curiosidad para terminar, comentar que no sólo está cargado de genes relacionados con el sistema nervioso, sino que además el cromosoma X alberga un buen número de genes implicados en el desarrollo testicular y su fisiología.

    El que se haya quedado con ganas de más, a Nature. O mejor, que se pase primero por Pharyngula.


    cromosoma X
    cromosoma Y

Referencias (TrackBacks)

URL de trackback de esta historia http://evolucionarios.blogalia.com//trackbacks/28254

Comentarios

1
De: Paleos Fecha: 2005-03-19 14:26

"...pero los genes responsables de la masculinidad están repartidos por todo el cromosoma, incluso el propio X."

No acabo de entender esa frase. Cuando dices "cromosoma", ¿te refieres a "genotipo"?

Un saludo.



2
De: BioMaxi Fecha: 2005-03-19 14:48

Vaya, una errata. Quería decir "los cromosomas", pero ya iba pensando en mencionar al propio X y me salió el singular. Corrigiendo... y gracias por el aviso :-)



3
De: BioMaxi Fecha: 2005-03-21 22:59

Por cierto, uno de los artículos publicados en Nature coincidiendo con la secuenciación del genoma dice que hay genes que se expresan aún estando en el cromosoma inactivado. Curiosamente, estos genes no son siempre los mismos, así que a mí me parece más que el proceso de silenciamiento es algo dinámico, no tan estático como lo imaginaban, así que al hacer los experimentos que han hecho han tomado "fotografías" estáticas que por lo tanto no tienen que coincidir de muestra a muestra puesto que no reflejan algo sistemático sino distintos momentos de un mecanismo dinámico.
Por no mencionar que el estudio está hecho en un sólo tipo de linaje celular, así que igual otras líneas tienen un comportamiento diferente.El artículo:
Carrel L. & Willard H. F. et al. Nature, 434. 400 - 404 (2005)
Y el comentario en Nature news.



4
De: Anónimo Fecha: 2005-11-06 00:20

son unos maricos



5
De: se Fecha: 2007-05-06 21:15

se



6
De: nazaret Fecha: 2007-05-17 04:13

Los cromosomas (término que significa "cuerpos coloreados", por la intensidad con la que fijan determinados colorantes al ser teñidos para poder observarlos al microscopio), son un componente del núcleo celular que sólo aparecen cuando la célula está en división, ya sea mitosis o meiosis; tiene una estructura filiforme, en forma de cadena lineal, más o menos alargada, en el caso de eucariotas, o en forma de anillo circular cerrado, en el caso de procariotas, y están compuestos por ácidos nucleicos y proteínas.



7
De: Curiosidades, curiosidades Fecha: 2007-06-25 12:22

Haber no entiendo: entonces la recombinación se da entre los X del padre y un X de la madre (elegido aleatoriamente) y luego el Y se lo queda o no se lo queda y en ese caso es hembra o varón???

Muchas gracias



8
De: El PaleoFreak Fecha: 2007-06-25 12:36

No te líes y repásate la meiosis ;o)
Hay buenos esquemas si buscas en Google.



9
De: stacey Fecha: 2007-08-19 00:27

que pereza



10
De: stacey Fecha: 2007-08-19 00:27

que pereza



11
De: stacey Fecha: 2007-08-19 00:29

mentira esta sumament interesante pude conseguir mi información *gracias*



12
De: HELIOFOBO Fecha: 2007-09-13 03:08

QUIERO SU OPINIÓN ACERCA DE LO SIGUIENTE: DESDE EL PUNTO DE VISTA EVOLUTIVO, EL CONCEPTO "LA NECESIDAD ,HACE EL ORGANO"; PUEDE INTERACTUAR CON EL CONCEPTO INVERSO " EL ORGANO HACE LA NECESIDAD",Y QUE EVIDENCIA CIENTÍFICA AL RESPECTO HAY. GRACIAS.



13
De: HELIOFOBO Fecha: 2007-09-13 03:08

QUIERO SU OPINIÓN ACERCA DE LO SIGUIENTE: DESDE EL PUNTO DE VISTA EVOLUTIVO, EL CONCEPTO "LA NECESIDAD ,HACE EL ORGANO"; PUEDE INTERACTUAR CON EL CONCEPTO INVERSO " EL ORGANO HACE LA NECESIDAD",Y QUE EVIDENCIA CIENTÍFICA AL RESPECTO HAY. GRACIAS.



14
De: Anónimo Fecha: 2007-10-11 12:40

...................



15
De: luis miguel vegas padrino Fecha: 2008-01-09 00:12

est super espectacular esta imformacion muchisimas grasias soy de venezuela de guarico alle de la pascua



16
De: Silvia Fecha: 2008-02-06 19:49

Una duda, en la foto son células lo que se ve o está a mayor aumento. Es porque quería hacerlo con mis alumnos. El año pasado lo hicimos y no se veía nada. Por favor contesta pronto porque me urge
Graciasssss



17
De: BioMaxi Fecha: 2008-02-06 20:02

Hola Silvia. Visto tu mail esto debe urgirte realmente mucho. "Eso" son nucleos celulares y la microfotografía está tomada con un microscopio electrónico. No sé si podrás disponer de tanta magnificación para tus prácticas.



18
De: km Fecha: 2008-03-09 17:02

jnbk



19
De: ingrid Fecha: 2008-08-21 02:19

no se si me podrian informar si el cromosoma x es la base el origen del gen
y quisiera saber que relacion guarda esto con el origen del gen es femenino y no masculino ...sobre la teoria creacionista...basandonos en etsudios...por que busco y no encuentro por favor si darian el dato de algun foro de genetica le agradeceré bastante soy alumna de ciencias...gracias por la ayuda que me pueda brindar.



20
De: investigadora Fecha: 2008-08-21 06:49

Hola Ingrid,

Saludos!

Aqui tienes una pagina que te puede ayudar:

www.sedin.org

Espero que te sirva de ayuda.

Investigadora



21
De: Cnidus Fecha: 2008-08-21 15:38

Ingrid

Si quieres aprender algo acerca del origen, evolución y ventajas biológicas del sexo, tienes una buena densidad de información en la Wikipedia: Evolución del sexo.



22
De: anny Fecha: 2008-09-11 22:37

estudio criminalistica y quisiera saber como es que se puede saber el sexo de una persona mediante el estudio del pelo...



23
De: amparo lima perz Fecha: 2008-09-20 03:58

quisiera saber aserca de las meiosis



24
De: amparo lima perz Fecha: 2008-09-20 03:59

quisiera saber aserca de las meiosis



25
De: amparo lima perz Fecha: 2008-09-20 03:59

quisiera saber aserca de las meiosis



26
De: Anónimo Fecha: 2009-03-23 00:23

bo sinver para para una veiga



27
De: katlen Fecha: 2009-10-16 16:34

pudreteeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeimbesillllllllllllllllllllllllllllllllllllll



28
De: juanita isabel Fecha: 2009-10-16 16:36

soy megra y fea



29
De: juanita isabel Fecha: 2009-10-16 16:36

soy megra y fea



30
De: juanita isabel Fecha: 2009-10-16 16:36

soy megra y fea



31
De: kainai Fecha: 2014-07-21 12:37

The post contains really beneficial information that will satisfy readers and can clarify things upon. You have you a nice way of presenting certain issue and seems to be so qualified mobile medical alert systems reviews



32
De: shoes for men formal Fecha: 2018-07-06 14:46

The business identities are nowadays flocking to get websites published, registered and hosted on the internet. Seeing to the exponential demand, the marker is witnessing mushrooming of a number of website design and development companies.Excellent website design come in many forms, it all depends on what your criteria is for the best web design. shoes for men formal



33
De: Pollowers Fecha: 2018-07-10 10:30

There are millions of people trying to make a blog and trying even harder to get it noticed. When making a good blog it is all about the post and the content. Spending too much time on the look and the ads is just going to leave you in the white space of Google with one big headache.[url=https://www.reddit.com/r/Pollowers/]Pollowers[/url]



34
De: Pollowers Fecha: 2018-07-10 10:31

There are millions of people trying to make a blog and trying even harder to get it noticed. When making a good blog it is all about the post and the content. Spending too much time on the look and the ads is just going to leave you in the white space of Google with one big headache.Pollowers



35
De: online college essay Fecha: 2018-07-12 14:21

Thanks for taking the time to discuss this, I feel strongly about it and love learning more on this topic. If possible, as you gain expertise, would you mind updating your blog with more information? It is extremely helpful for me.



36
De: Combat Sports Fecha: 2018-07-18 10:06

You have truly shared a useful and intriguing blog access with individuals. I am really glad to discover this website online and did enjoy analyzing useful articles posted right here. The ideas of the writer were exquisite and great, thanks for the share and keep submit coming. Combat Sports



37
De: click this site Fecha: 2018-07-21 12:29

You make so many great points here that I read your article a couple of times. Your views are in accordance with my own for the most part. This is great content for your readers.



38
De: westcoast420express.ca Fecha: 2018-07-30 16:33

This is really a nice and informative, containing all information and also has a great impact on the new technology. Thanks for sharing it



39
De: online study resources Fecha: 2018-08-01 10:02

I really thank you for the valuable info on this great subject and look forward to more great posts. Thanks a lot for enjoying this beauty article with me. I am appreciating it very much! Looking forward to another great article. Good luck to the author! All the best!



40
De: rental mobil jogja Fecha: 2018-08-02 14:08

I can see that you are an expert at your field! I am launching a website soon, and your information will be very useful for me.. Thanks for all your help and wishing you all the success in your business.



41
De: small business marketing strategies Fecha: 2018-08-09 15:15

I'm glad I found this web site, I couldn't find any knowledge on this matter prior to.Also operate a site and if you are ever interested in doing some visitor writing for me if possible feel free to let me know, i am always look for people to check out my web site.



42
De: http://www.keralatoursandholidays.com/obtain-some-tricks-to-play-return-man-1-game-online/ Fecha: 2018-08-10 16:48

Blogs often fail because their owners run out of topics to write about, and in a fit of frustration and writer's block, they give up. People have trouble coming up with ideas oftentimes, and that's okay. It doesn't say anything bad about your ability as a blogger. If you are running a blog make sure that you give your audience everything they crave in order to keep them coming back.



43
De: search engine marketing Fecha: 2018-08-15 16:54

This is really a nice and informative, containing all information and also has a great impact on the new technology. Thanks for sharing it



44
De: ccfftoronto.ca Fecha: 2018-08-27 16:15

Great post I would like to thank you for the efforts you have made in writing this interesting and knowledgeable article.



45
De: Michigan Personal Injury Law Firm Fecha: 2018-08-28 15:37

I admit, I have not been on this web page in a long time... however it was another joy to see It is such an important topic and ignored by so many, even professionals. professionals. I thank you to help making people more aware of possible issues.



46
De: Servane Barrau Designs Fecha: 2018-09-18 09:22

When you take a seat all the way down to write a blog put up your blog is already formatted and laid out a certain manner. That leaves you with a few picks to make in the way you layout your blog posts. To format an excellent weblog publish it is important to reflect onconsideration on the way you need your put up to look. You have an idea for a weblog, however you do not know the way to cross about writing for it. What are the steps you need to to take to realize a way to write an excellent blog?



47
De: best cleaning services Fecha: 2018-09-19 13:37

If you are obsessed to possess associate degree excellent weblog, the necessary factor to urge it's miles simply on your self. it's possible handiest if you're associate degree sensible web log author. However, to be associate degree notable author is not straightforward. So, here ar some recommendations which will assist you type your self turning into an impressive web log author.



48
De: repair auto mechanic Fecha: 2018-09-19 15:08

Need to notice a correct web log place up idea? Then allow Google ask for engine provide you with a complete array of thoughts to settle on from. simply by approach of putting ' weblog ideas' among the ask for tool, you come upon several websites with hints for what to put in writing for your weblog. Writing an honest web log place up isn't something quite a technology associate degreed an design that may be perfect. sort of a sculptor gaining data of to sculpt models out of stone, the equal goes with a blogger.



49
De: look at this site Fecha: 2018-09-24 09:55

Your weblog name says the entire factor generally you, yet what makes a staggering name in order to depictions and what makes a horrendous title so it'll drive family away? you'll best have this one peril to ask it revise. On the off chance that you have got a web log you're likely pleasantly mindful that filling your weblog with content material could likewise be awfully time-ingesting. you wish to expressly state down a radiant weblog present that gets intrigue each out of your arrival visitors and from the motors like google.



50
De: automotive locksmith tools Fecha: 2018-09-25 14:09

Your blog elect says masses thing roughly you, all the same what makes a profitable letter of credence so separately from paintings and what makes a bad catch a glimpse of in censure to alarm clan off? You manage simplest have one threat to gat what is coming to one it right. Discover four material you behooves get as a process to blew one cool your weblog from a digital deadland to a living moment community! gat an eyeful of to explain greater.



51
De: advance bankruptcy Fecha: 2018-09-25 15:16

Nearly all will agree on achievement in net marketing will frequently hinge round whether or not a first rate website is employed as a promotional device. It is a excellent internet web page submit with out fail. Not too many people could really, the manner you simply did. I am impressed that there are such a lot of data about this challenge that has been uncovered and you’ve defeated yourself this time, most do recognize the want for making and first rate website.



52
De: find out this here Fecha: 2018-09-26 09:54

Websites much of the time bomb because of the reality their proprietors come up short on themes to expound on, and in a fit as a fiddle of disappointment and creator's square, they surrender. Individuals have the issue creating with thoughts by and large, and that is k. It would not say something awful in regards to your capacity as a blogger. On the off chance that you are strolling a blog guarantee that you convey your objective market the entire part they ache for which will hold them coming return. find out this here



53
De: See more Fecha: 2018-09-27 12:50

A fitting weblog needs to get the peruser's leverage. The most essential factor generally creating a blog is to make it captivating. No one needs to examine an inclination that has been shared one hundred events beforehand. There's not the slightest bit like a blockbuster movie to transport you to an alternate universe. In any case, the extravagant shouldn't stop when the film does.



54
De: ECA Stack Fecha: 2018-09-28 14:15

I failed to apprehend that this trouble changed into so essential and so familiar. You actually positioned it in mind-set for me. Years ago I determined to-do lists vastly usefully, so if you revel in has been that that is a long way greater beneficial, that’s very tempting.I’ll deliver this an try. You truly inspired her. Thank you for providing the essential, relaxed, edifying now not to say clean recommendations regarding your situation to Evelyn you are so proper. I'm there with you.



55
De: finance real estate agent Fecha: 2018-10-01 13:50

As the company deal with packing and moving they need to be amenable to all legal and safety rules and regulations. These norms referred to national-level and state-level rules which need to be complied with prior to taking up any moving assignments. A solid emblage of involvement in managing atmosphere related dangers as of now exists in the catastrophe chance decrease network. Additionally, the worldwide catastrophe administration network, and in addition sectoral networks, are progressively concentrating their endeavors on building flexibility into speculations and improvement.



56
De: ข่าวกีฬา Fecha: 2018-10-01 14:30

This is such a great resource that you are providing and you give it away for free.



57
De: jui residences showflat Fecha: 2018-10-02 10:07

Your website is really cool and this is a great inspiring article. Thank you so much.



58
De: prislusni uredjaji Fecha: 2018-10-03 13:31

This is a smart blog. I mean it. You have so much knowledge about this issue, and so much passion. You also know how to make people rally behind it, obviously from the responses.



59
De: loafers shoes prices in Pakistan Fecha: 2018-10-03 15:09

So much of advantages as far as the Universal Contour Wrap is concerned. I actually like your mail and I am waiting for your next item and expecting some truly incredible data available there. Thank you so much for your good data sharing. In some instances, these advances area unit even bought with future credit score cards receipts. the quantity of the money enhance depends on the money score rating of a business and its credit score cards sales.



60
De: gmod free online Fecha: 2018-10-05 12:49

It is ending up obvious that microorganisms have a momentous capacity to recreate their genomes even with ecological anxieties, and that at times their aggregate associations with infections might be urgent to this. In such a circumstance, how substantial is the specific idea of a life form in detachment? It appears that there is a progression of vitality motion and instructive exchange from the genome up through cells, network, virosphere, and condition.



61
De: Woodleigh Residences psf Fecha: 2018-10-06 08:34

This is a great inspiring article.I am pretty much pleased with your good work.You put really very helpful information...



62
De: web development Fecha: 2018-10-06 13:20

The inconvenience you we secured above is genuinely regarded gifted for all people to work out. the possibility of your article is tremendous and it'll comprehend a phenomenal way. pushed toward getting to be started to offer money related help to individuals who can't hold up under the whole advantage of creating private assets.



63
De: Webbtips Fecha: 2018-10-06 15:58

I would like to say that this blog really convinced me to do it! Thanks, very good post.



64
De: juniper hill singapore siteplan Fecha: 2018-10-07 10:48

You completed a few fine points there. I did a search on the subject and found nearly all persons will go along with with your blog.



65
De: Marido de aluguel Fecha: 2018-10-08 15:55

Thank you for some other informative blog. Where else could I get that type of information written in such an ideal means? I have a mission that I’m just now working on, and I have been at the look out for such information.



66
De: what to do in hualien Fecha: 2018-10-11 14:20

I went over this website and I believe you have a lot of wonderful information, saved to my bookmarks



67
De: things to do in hualien Fecha: 2018-10-11 19:50

i am always looking for some free stuffs over the internet. there are also some companies which gives free samples.



68
De: Printers Leeds Fecha: 2018-10-12 08:59

This article is an appealing wealth of informative data that is interesting and well-written. I commend your hard work on this and thank you for this information. You’ve got what it takes to get attention.



69
De: urlaub mit snowtimes Fecha: 2018-10-14 13:27

Interesting topic for a blog. I have been searching the Internet for fun and came upon your website. Fabulous post. Thanks a ton for sharing your knowledge! It is great to see that some people still put in an effort into managing their websites. I'll be sure to check back again real soon.



70
De: Track status Fecha: 2018-10-15 07:46

These are some great tools that i definitely use for SEO work. This is a great list to use in the future..



71
De: Taroko National Park Fecha: 2018-10-18 13:24

Excellent article. Very interesting to read. I really love to read such a nice article. Thanks! keep rocking.



72
De: green island taiwan Fecha: 2018-10-18 14:19

Hi! Thanks for the great information you have provided! You have touched on crucuial points!



73
De: Vidare till webbplatsen nu Fecha: 2018-10-24 10:10

Great articles and great layout. Your blog post deserves all of the positive feedback it’s been getting.



74
De: cheap family law Fecha: 2018-10-25 14:07

It's so correct thus amazing. I am generally confused. I am trusting in which you hold to do your work like this inside the predetermination, moreover, I figure this is an illuminating setup and it's miles to an extraordinary degree supportive and educated. thusly, I should need to thank you for the endeavors you have made in making.



75
De: morgan Fecha: 2018-10-25 16:09

I found your site by mess up when I was chasing yahoo down this skin break out an issue, I should express your site is to a great degree valuable I in like manner love the framework, its bewildering!. I don't have space plan savvy right presently to totally peruse your site yet I have bookmarked it and moreover incorporate your RSS channels.



76
De: roofing sheets company Fecha: 2018-10-25 16:10

I found your site by mess up when I was chasing yahoo down this skin break out an issue, I should express your site is to a great degree valuable I in like manner love the framework, its bewildering!. I don't have space plan savvy right presently to totally peruse your site yet I have bookmarked it and moreover incorporate your RSS channels.



77
De: Klicka vidare till webbplatsen Fecha: 2018-10-26 16:49

Good article, but it would be better if in future you can share more about this subject. Keep posting.



78
De: Klicka vidare till sidan Fecha: 2018-10-27 09:44

This is highly information, crisp and clear. I think that everything has been described in systematic manner so that reader could get maximum information and learn many things.



79
De: Qixingtan Beach Fecha: 2018-10-27 20:53

You have done a great job on this article. It’s very readable and highly intelligent. You have even managed to make it understandable and easy to read. You have some real writing talent. Thank you.



80
De: Kajal Thakkar Fecha: 2018-10-28 04:32

A very informational and good post. I like the way you have chosen the topic and write about it. Keep it up.

http://www.kajalthakkar.com/


Kajal Thakkar


Pune Escorts


Pune Call Girls


Pune Independent Escorts


Pune VIP Escorts


Pune Elite Escorts


Escorts in Pune


Pune Escorts Services



81
De: Taniya kapoor Fecha: 2018-10-28 04:37

A very motivating and inspiring article. What a way to bring up a topic and write about it. Great!! Good Job!!

http://www.taniyakapoor.in/


Mumbai Escorts


Mumbai Call Girls


Mumbai Independent Escorts


Mumbai Independent Escorts


Mumbai Elite Escorts


Mumbai VIP Escorts


Escorts in Mumbai


Mumbai Escorts Services




82
De: Sweety Patel Fecha: 2018-10-28 04:41

This is a kind of Article i was searching. Really a good topic to write upon and very excellent way of writing it. A great job was done.

http://www.sweetypatel.com/


Mumbai Escorts


Mumbai Call Girls


Mumbai Independent Escorts


Mumbai Independent Escorts


Mumbai Elite Escorts


Mumbai VIP Escorts


Escorts in Mumbai


Mumbai Escorts Services




83
De: Anika Kaur Fecha: 2018-10-28 04:46

This topic and post is very interesting. What a nice way of writing it and explaing it. Great post. Keep it up!!.


http://www.anikakaur.com/


Mumbai Escorts


Mumbai Call Girls


Mumbai Independent Escorts


Mumbai Independent Escorts


Mumbai Elite Escorts


Mumbai VIP Escorts


Escorts in Mumbai


Mumbai Escorts Services




84
De: Se mer information om Wordpress bloggen Fecha: 2018-10-31 12:58

I am glad you take pride in what you write. This makes you stand way out from many other writers that push poorly written content.



85
De: Free Hindi Mp3 Songs Download Fecha: 2018-11-08 14:24

This is an awesome blog. You provide very useful data. Free Hindi Mp3 Songs Download



86
De: gaming Fecha: 2018-11-11 10:38

The information you have posted is very useful. The sites you have referred was good. Thanks for sharing...



87
De: shakadang trail Fecha: 2018-11-12 15:19

I can see that you are an expert at your field! I am launching a website soon, and your information will be very useful for me.. Thanks for all your help and wishing you all the success in your business.



Nombre
Correo-e
URL
Dirección IP: 54.162.166.76 (9496fb8397)
Comentario
¿Cuánto es: diez mil + uno?

Inicio > Historias > Historia de dos cromosomas